The factor XIa inhibitor asundexian, did not cause excess bleeding when given with antiplatelets in a pair of large phase 2, dose-ranging trials in different secondary-prevention settings. ESCCongress
, in patients with AF. In that trial, asundexian supressed factor XIa activity about as thoroughly as it did in PACIFIC-AMI.it is launching a phase 3 asundexian program that is expected to involve tens of thousands of patients, starting with trials called OCEANIC-AF and OCEANIC-STROKE.
In PACIFIC-AMI,"there was no clear signal toward either efficacy or bleeding," observed Michelle L. O'Donoghue, MD, MPH, Brigham and Women's Hospital, Boston, the invited discussant, after the presentation. Still, said Alexander,"of the doses we studied in PACIFIC-AMI, the 50 mg dose looks very attractive. It doesn't seem to cause bleeding, at least not in a modest-sized phase 2 trial. And it almost completely inhibits factor XI, so taking that forward would be interesting."
Österreich Neuesten Nachrichten, Österreich Schlagzeilen
Similar News:Sie können auch ähnliche Nachrichten wie diese lesen, die wir aus anderen Nachrichtenquellen gesammelt haben.
ALL-HEART: No Benefit of Allopurinol in Ischemic Heart DiseaseAllopurinol, a drug commonly used to treat gout, provided no benefit in terms of reducing CV events in patients with ischemic heart disease, new randomized trial results show. MedTwitter
Weiterlesen »
Dry summers could mean trouble for use of lake water for North Slope ice roads, study says - Alaska Public MediaGuidelines for taking water from North Slope tundra lakes should be refined to consider rare summer droughts and other factors, study says.
Weiterlesen »
Do SGLT2 Inhibitors DELIVER in All Heart Failure?The investigators of the DELIVER trial and others suggest that all patients with heart failure get SGLT2 inhibitors, but drjohnm sees differing effects depending on ejection fraction. ESCCongress MedTwitter
Weiterlesen »
Work beginning on 50-acre Walker County multi-use developmentIn addition to supporting 16 full-time construction jobs, the project is expected to create 100 direct jobs and 30 indirect jobs.
Weiterlesen »
How to Switch From Google Authenticator to Another 2FA AppYes, you can choose another two-factor authentication app without getting locked out of your accounts.
Weiterlesen »
Ageism is about more than just hurt feelingsStudies have shown that holding negative views about getting older is associated with worse health outcomes.
Weiterlesen »