Researchers find accumulation of amyloid beta protein at sites of potassium depletion in the brain
calculation for K isotopes to draw from. However, and while the two cannot be considered directly analogous, we can make first-order inferences by looking to Cu isotopes. Perhaps most relevant is the observation of a light Cu isotope excursion in human blood serum from ovarian cancer, as this provides a rough analogue with respect to physical reservoir size . In Toubhans et al.
However, from first principles and Fujii et al.it is reasonable to make the plausible assumption of heavy metal isotope enrichment when the metal is cellularly bound as opposed to “free” , and that the typical isotopic offset between the two is often larger than 0.5‰; this would suggest a similar scenario for K.
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