The results are in
There is another big Euromillions jackpot to be won in Tuesday's draw.
And if you thought that was a lot of money a Powerball ticket holder over in the USA has won a gigantic £1.76 billion.
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“Sheer incompetence or the continuing war against motorists?” Drivers claim cycle hangar is “deliberately” taking up two car parking spaces; An American car in the Netherlands + more on the live blog“Sheer incompetence or the continuing war against motorists?” Drivers claim new cycle hangar is “deliberately” taking up two car parking spaces cycling
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Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk - BMC MedicineBackground Observational epidemiological studies suggest a link between several factors related to ovulation and reproductive function and endometrial cancer (EC) risk; however, it is not clear whether these relationships are causal, and whether the risk factors act independently of each other. The aim of this study was to investigate putative causal relationships between the number of live births, age at last live birth, and years ovulating and EC risk. Methods We conducted a series of observational analyses to investigate various risk factors and EC risk in the UK Biobank (UKBB). Additionally, multivariate analysis was performed to elucidate the relationship between the number of live births, age at last live birth, and years ovulating and other related factors such as age at natural menopause, age at menarche, and body mass index (BMI). Secondly, we used Mendelian randomization (MR) to assess if these observed relationships were causal. Genome-wide significant single nucleotide polymorphisms (SNPs) were extracted from previous studies of woman’s number of live births, age at menopause and menarche, and BMI. We conducted a genome-wide association analysis using the UKBB to identify SNPs associated with years ovulating, years using the contraceptive pill, and age at last live birth. Results We found evidence for a causal effect of the number of live births (inverse variance weighted (IVW) odds ratio (OR): 0.537, p = 0.006), the number of years ovulating (IVW OR: 1.051, p = 0.014), in addition to the known risk factors BMI, age at menarche, and age at menopause on EC risk in the univariate MR analyses. Due to the close relationships between these factors, we followed up with multivariable MR (MVMR) analysis. Results from the MVMR analysis showed that number of live births had a causal effect on EC risk (OR: 0.783, p=0.036) independent of BMI, age at menarche and age at menopause. Conclusions MVMR analysis showed that the number of live births causally reduced the ri
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Cooler Air Makes a Comeback TuesdayWhile you may want to vote it out, the cool air has returned. Its two-day visit is short-lived, however, as the milder winds from the south bring back the 60s at the tail end of the week. We’ll only manage to make the low 50s Tuesday, and perhaps sneak into the mid-50s (away from the coast) Wednesday. Overnight temps will…
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Rail disruption: Many services to start late on TuesdayFirst trains will run later on many lines - as Avanti West Coast says services are limited all day.
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Every time and place for King Charles' Leeds tour on TuesdayHis Majesty will be visiting Leeds Library and Art Gallery and Leeds Building Society
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