If delivered at the right time, hormone doses in birth control could be way lower, according to a mathematical model.
Estrogen causes hormonal birth controls’ most serious and rare side effects, such as stroke and heart attack. The hormone is also at the root of some of the contraceptives’ less serious but still annoying symptoms, including nausea and headaches.
The researchers modeled how consistent doses of either progesterone or estrogen — at about the levels currently found in common birth control options — prevented ovulation throughout a menstrual cycle. Then, the team applied a mathematical strategy called optimal control theory to determine the lowest amount of estrogen or progesterone able to halt ovulation.
“We did not only lower the dosage, but we also identified when to administer the contraceptive,” de los Reyes says.
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