The strikes are part of a long-running pay dispute, with junior doctors saying they have suffered 15 years of 'pay erosion'.
Up to 250,000 appointments and operations are at risk in England's hospitals when junior doctors walk off the job for four days next week.
NHS national medical director Professor Sir Stephen Powis said:"This next round of strikes will see unparalleled levels of disruption, and we are very concerned about the potential severity of impact on patients and services across the country. The NHS will prioritise emergency, critical and neonatal care, as well as maternity and trauma services, but it is still expected that many thousands of appointments - including for cancer care - will have to be postponed.
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