East Asian people are more likely to develop a more aggressive type of stomach cancer because of their higher likelihood of alcohol intolerance, according to a new study led by researchers in Japan.
People of East Asian heritage are much more likely to inherit a genetic mutation not commonly seen in other ethnic groups that compromises the ability to metabolize alcohol. This is the same mutation responsible for the facial redness after drinking often referred to as “Asian glow,” according to study co-author Tatsuhiro Shibata.
Shibata, who heads the Division of Cancer Genomics at Japan’s National Cancer Center Research Institute, said he hopes these findings make it easier for researchers to detect patterns in the onset of stomach cancer.
“That leads to essentially chronic inflammation within the stomach,” Goel said. “And eventually, over years and years of repeated exposure, these patients tend to get increased incidence of gastric cancer.” Cases of gastric cancer are also statistically much more common in men than in women. But this makes sense from a behavioral perspective, Goel said, rather than being due to any inherent genetic factors. Data show East Asian men tend toAs with any type of cancer, early detection is crucial to treating stomach cancer. But due to its relative infrequency in the West compared to other types, such as breast, cervical and colon cancer, the United States does not routinely screen for gastric cancer.
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