Early use of dexamethasone associated with reduced mortality in hospitalized COVID-19 requiring breathing support COVID19 Dexamethasone HospitalizedPatients MortalityReduction MechanicalVentilation SupplementalOxygen JAMANetworkOpen
Study: Dexamethasone for Inpatients With COVID-19 in a National Cohort. Image Credit: Terelyuk / Shutterstock
About the study In the present national-level multicenter retrospective cohort study, researchers investigated whether early administration of dexamethasone among hospitalized individuals with SARS-CoV-2 infection-associated pulmonary disease in the United States could improve in-hospital disease outcomes.
Key Takeaways COVID-19 was diagnosed using the International Classification of Diseases, Tenth Revision codes. Supplemental oxygen levels were categorized using a modified version of the World Health Organization COVID-19 ordinal scale. Individuals with consecutively missing ordinal scale data and patients receiving dexamethasone prior to hospitalization were excluded from the analysis.
On the contrary, any cause of within-hospital deaths or discharge for hospice care did not decrease for individuals receiving dexamethasone without any oxygen supplementation and/or NIPPV, with aOR values of 0.9 and 0.9, respectively. Of note, dexamethasone conferred more benefits to individuals with comorbid conditions.
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