FMT is safe and highly effective as first-line therapy for patients with first or second Clostridioides difficile infection.
The investigators noted that the participants represented a real-world patient population, so the data support FMT"as a necessary, effective first-line option" in routine management of"Previous studies have demonstrated clinical cure rates [with FMT] of up to 92%," Baunwall and colleagues wrote."Early use of FMT for first or secondinfection has therapeutic potential, but no formal randomized trials to support use of the approach as a first-line therapy have been done.
Most patients experienced adverse events, including 20 in the FMT group and all 21 in the placebo group, although most were transient and nonserious. The most common adverse events were diarrhea, which occurred more frequently in the FMT group , followed by abdominal pain and nausea . Turner said his confidence would go"way, way up" if the findings were reproduced in a larger study. Ideally, these future trials would useDr John Kao
Despite this confidence in FMT as an efficacious first-line option, Kao said it is unlikely to be routinely used in this way anytime soon, even if a larger trial echoes the present results.
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