Do hypertension, dyslipidemia, and new-onset diabetes mellitus play a part in post-COVID sequelae? MDPIOpenAccess PUMS_tweets COVID19 SARSCoV2 Hypertension Diabetes Dyslipidemia
By Dr. Chinta SidharthanOct 18 2022Reviewed by Aimee Molineux A recent review published in the International Journal of Environmental Research and Public Health evaluated the current research on incidences of hypertension, new-onset diabetes mellitus, and dyslipidemia as possible sequelae of coronavirus disease 2019 .
About the study The present review examined recent studies on persistent changes in lipid profiles, blood glucose levels, and blood pressure to determine whether long-COVID manifestations include dyslipidemia, new-onset diabetes mellitus, and hypertension. Results The results indicated that new-onset diabetes mellitus, dyslipidemia, and hypertension are possible long-COVID outcomes. A significant number of patients exhibited hyperglycemia during the months after recovery, and meta-analysis indicated a 59% increase in the risk of developing diabetes mellitus after SARS-CoV-2 infection. Studies also noted elevated systolic blood pressure and changes in diastolic blood pressure in the three months after recovery.
Additionally, the increased secretion of cytokines during COVID-19, known as a cytokine storm, results in a surge in inflammation, which could trigger insulin resistance and overstimulate the beta cells. Furthermore, post-translational protein modifications during SARS-CoV-2 infections could also activate T-cells, causing autoimmune disorders such as diabetes mellitus type 1.
Österreich Neuesten Nachrichten, Österreich Schlagzeilen
Similar News:Sie können auch ähnliche Nachrichten wie diese lesen, die wir aus anderen Nachrichtenquellen gesammelt haben.
Comparison of Long-Term Complications of COVID-19 Illness among a Diverse Sample of Children by MIS-C StatusMost pediatric COVID-19 cases are asymptomatic; however, a small number of children are diagnosed with multisystem inflammatory syndrome in children (MIS-C), a rare but severe condition that is associated with SARS-CoV-2 infection. Persistent symptoms of COVID-19 illness in children diagnosed with/without MIS-C is largely unknown. A retrospective EHR review of patients with COVID-19 illness from one pediatric healthcare system to assess the presence of acute (<30 days) and chronic (≥30, 60–120, and >120 days) long-term COVID symptoms was conducted. Patients/caregivers completed a follow-up survey from March 2021 to January 2022 to assess the presence of long COVID. Results showed that non-MIS-C children (n=286; 54.49% Hispanic; 19.23% non-Hispanic Black; 5.77% other ethnicity; 79.49% government insurance) were younger (mean age 6.43 years [SD 5.95]) versus MIS-C (n=26) children (mean age 9.08 years, [SD 4.86]) (p=0.032). A share of 11.5% of children with MIS-C and 37.8% without MIS-C reported acute long COVID while 26.9% and 15.3% reported chronic long COVID, respectively. Females were almost twice as likely to report long symptoms versus males and those with private insurance were 66% less likely to report long symptoms versus those with government insurance. In conclusion, a substantial proportion of ethnically diverse children from low resource backgrounds with severe COVID illness are reporting long-term impacts. Findings can inform pediatric professionals about this vulnerable population in post-COVID-19 recovery efforts.
Weiterlesen »
Pathophysiology of Post-COVID syndromes: a new perspective - Virology JournalMost COVID-19 patients recovered with low mortality; however, some patients experienced long-term symptoms described as “long-COVID” or “Post-COVID syndrome” (PCS). Patients may have persisting symptoms for weeks after acute SARS-CoV-2 infection, including dyspnea, fatigue, myalgia, insomnia, cognitive and olfactory disorders. These symptoms may last for months in some patients. PCS may progress in association with the development of mast cell activation syndrome (MCAS), which is a distinct kind of mast cell activation disorder, characterized by hyper-activation of mast cells with inappropriate and excessive release of chemical mediators. COVID-19 survivors, mainly women, and patients with persistent severe fatigue for 10 weeks after recovery with a history of neuropsychiatric disorders are more prone to develop PCS. High D-dimer levels and blood urea nitrogen were observed to be risk factors associated with pulmonary dysfunction in COVID-19 survivors 3 months post-hospital discharge with the development of PCS. PCS has systemic manifestations that resolve with time with no further complications. However, the final outcomes of PCS are chiefly unknown. Persistence of inflammatory reactions, autoimmune mimicry, and reactivation of pathogens together with host microbiome alterations may contribute to the development of PCS. The deregulated release of inflammatory mediators in MCAS produces extraordinary symptoms in patients with PCS. The development of MCAS during the course of SARS-CoV-2 infection is correlated to COVID-19 severity and the development of PCS. Therefore, MCAS is treated by antihistamines, inhibition of synthesis of mediators, inhibition of mediator release, and inhibition of degranulation of mast cells.
Weiterlesen »
Study finds mild Covid-19 during pregnancy ‘exhausts placenta and damages immune response’Covid-19 in pregnancy may “exhaust” the placenta and cause damage to its immune response.
Weiterlesen »
Study investigates spatial variability in increasing public awareness for voluntary COVID-19 testingStudy investigates spatial variability in increasing public awareness for voluntary COVID-19 testing Elsevierconnect SpatialVariability COVID19 SARSCoV2 Testing VoluntaryTesting
Weiterlesen »
Reduced cardiac function identified in severe COVID-19 patients in new studyReduced cardiac function identified in severe COVID-19 patients in new study elsevierconnect ucatolica SARSCoV2 SevereCOVID CardiacFunction
Weiterlesen »
78 Lancashire neighbourhoods where Covid-19 cases are risingThe number of areas with rates over 100 has risen from 73 to 78 in one week
Weiterlesen »