Scientists have discovered new roles for the pseudokinase PEAK3 in growth factor signaling and cell invasiveness—supporting the idea that PEAK3 could be a target for new treatments for cancer. SciSignal
Pseudokinases are proteins that structurally resemble kinases but lack catalytic activity and contribute to various signaling pathways as scaffolds. Houinvestigated the regulation and interactome of the pseudokinase
and PEAK2 are implicated in cancer cell migration and metastasis. We characterized the regulation and role of the third family member , it bound to the adaptors Grb2 and CrkII. However, unlike dephosphorylation mediated by the phosphatase PTPN12. Overexpressing
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