Diamond earrings and an Aston Martin: Luxury fundraising night for Much Hoole mum trying to “kick cancer’s ass”
- a mini break in the LakesSam's sister Zoë Turbefield said:"Funding the therapy will mean that Sam has a chance at seeing her children grow up, she's such a fighter there's no way she's ever going to give up on seeing that happen.
"This treatment will give her the chance of a life, and I might sound naive for hoping but I believe she has a chance to beat it, but it's going to be a real battle. "I really hope the amazing support we've received so far continues, Sam's fight is just beginning and knowing we have so many people behind her is just incredible."Family is absolutely everything to her. Seeing all the things people are doing to help raise money has massively helped boost her spirits, she reads every single message of support she receives, it really fuels her.
"There has been so much goodwill in such hard times that it's impossible not to be moved by the comments and efforts people are going to for her."
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In critically ill patients, anti-anaerobic antibiotics increase risk of adverse clinical outcomesBackground Critically ill patients routinely receive antibiotics with activity against anaerobic gut bacteria. Yet in other disease states and animal models, gut anaerobes are protective against pneumonia, organ failure, and mortality. We therefore designed a translational series of analyses and experiments to determine the effects of anti-anaerobic antibiotics on the risk of adverse clinical outcomes among critically ill patients. Methods We conducted a retrospective single-center cohort study of 3032 critically ill patients, comparing patients who did and did not receive early anti-anaerobic antibiotics. We compared ICU outcomes (ventilator-associated pneumonia[VAP]-free survival, infection-free survival, overall survival) in all patients, and changes in gut microbiota in a 116-patient subcohort. In murine models, we studied the effects of anaerobe depletion in infectious ( K. pneumoniae and S. aureus pneumonia) and noninfectious ( hyperoxia ) injury models. Results Early administration of anti-anaerobic antibiotics was associated with decreased VAP-free survival (HR 1.24, 95% CI 1.06–1.45), infection-free survival (1.22, 95% CI 1.09–1.38), and overall survival (HR 1.14, 95% CI 1.02–1.28). Patients who received anti-anaerobic antibiotics had decreased initial gut bacterial density (p=0.00038), increased microbiome expansion during hospitalisation (p=0.011), and domination by Enterobacteriaceae spp. (p=0.045). Enterobacteriaceae were also enriched among respiratory pathogens in anti-anaerobic treated patients (p|2.2×10−16). In murine models, treatment with anti-anaerobic antibiotics increased susceptibility to Enterobacteriaceae pneumonia (p|0.05) and increased the lethality of hyperoxia (p=0.0002). Conclusions In critically ill patients, early treatment with anti-anaerobic antibiotics is associated with increased mortality. Mechanisms may include enrichment of the gut with respiratory pathogens, but increased mortality is incompletely explained by infections alone
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