About 27% of people who get COVID-19 have a rebound of their symptoms, regardless of whether they took the antiviral treatment Paxlovid.
Symptoms can return after the person’s condition improves, and the symptoms can be better or worse than the original bout of illness, the study authors said.
Smith and colleagues looked at viral and symptom rebound in 568 untreated patients with mild to moderate COVID-19 who received a placebo in afor one of Eli Lilly’s monoclonal antibody treatments. The researchers collected nasal swabs on days 0 to14, 21, and 28, and the people in the study recorded how severe their symptoms were from days 0 to 28.
What’s more, about 12% of people had a “viral rebound,” which means they tested positive again after several days of testing negative. This has been documented among people who have taken Paxlovid, including President Joe Biden, but the study found that viral rebound can occur regardless of treatment.
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