A break in taking methotrexate could improve how well vaccines work, a trial led by University of Nottingham suggests
More than a million vulnerable people could improve their protection against Covid by taking a short break from medication after a booster jab, a trial suggests.
Until now, UK guidance has been to continue taking methotrexate after a Covid booster - but in the US, patients have been advised to stop for a week.Prof Abhishek Abhishek, from the University of Nottingham, who led the trial, said he was "extremely pleased" with the initial results. "Implementing these results could vastly improve the protection provided by boosters against Covid-19, for millions of people living with these conditions," Prof Abhishek said."We hope this evidence is the next step in helping them with their lives going forward."However, Prof Neil Mabbott, from the University of Edinburgh, said unanswered questions included whether this could reduce serious Covid illness and the risk of admission to hospital.
In the trial, 254 adults, from 26 NHS hospitals across England and Wales, who had just had a Covid booster jab, were equally divided and asked to either:Four weeks later, levels of spike antibodies in the blood - which block the virus from infecting cells inside the body - were twice as high in the first group as the second group, and they remained noticeably higher after 12 weeks.
"This has important implications for future vaccination strategy in this immunosuppressed patient group."
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