COVID-19 risk: natural infection vs. vaccine induced immunity SSRN PittTweet covid COVID19 SARSCoV2 natural vaccination
By Pooja Toshniwal PahariaMay 4 2023Reviewed by Lily Ramsey, LLM In a recent study posted to the SSRN* preprint server, researchers evaluated the immune protection conferred by previous severe acute respiratory syndrome coronavirus 2 infection and/or coronavirus disease 2019 vaccines against reinfection.
The authors searched the PubMed Central database between 1 March 2020 and 1 June 2022 for randomized controlled trials and other studies assessing protection against SARS-CoV-2 reinfection. Individual-level data were obtained from United States government-funded harmonized COVID-19 vaccine randomized controlled trials evaluating Janssen’s Ad26.COV2.S, Moderna’s mRNA-1273, Novovax’s NVX-CoV2373, and AstraZeneca’s AZD1222 vaccines.
Data adjustments were made for race, sex, age, ethnicity, comorbidities, and SARS-CoV-2 exposure risk at baseline. All trials identified individuals with prior COVID-19 history using SARS-CoV-2 nucleocapsid protein-based immunoassays. Among one-dose Janssen vaccinees, hybrid immunity provided greater immune protection compared to vaccinations alone . Too few SARS-CoV-2 infections occurred in other vaccine trials to infer data by comparing hybrid immune protection to that conferred by vaccination.
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