SARS-CoV-2’s public health impact is worse than that of heart disease or cancer, study claims; others say the work may overestimate harm for the general population
This time, the team looked at 80 health problems—from fatigue and other symptoms commonly associated with Long Covid to neurodegenerative disease—and general risk of death or hospitalization up to 2 years postinfection. They included data from about 140,000 people who tested positive for SARS-CoV-2 in 2020 and 6 million people with no record of infection that year.
“This is a rigorous study that matches what we’ve been hearing from [clinicians and patients] for years,” says Francesca Beaudoin, a clinical epidemiologist at the Brown University School of Public Health who was not involved in the work. Although COVID-19 is directly causing some of these health problems, she adds, it could exacerbate others or accelerate their onset.
“[Older] men are some of the people most afflicted by acute COVID,” says Shawn Murphy, a neurologist and bioinformatician at Harvard Medical School and Massachusetts General Hospital. Although the authors tried to correct for this statistically, still, “We need to be careful about doing these extrapolations.”
Duke University statistician Fan Li adds that greater use of health care—a typical consequence of getting COVID-19—increases a person’s chances of being diagnosed with other conditions. This also skews apparent differences between infected people and controls, and isn’t adequately addressed in the study, she says.
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