A common blood condition associated with an increased risk of several diseases unexpectedly appears to lower the risk of Alzheimer's disease.
) that lives in our bone marrow ends up with a mutation allowing it to create mutant blood cells stronger than their peers. CHIP can form in otherwise healthy people and doesn't have noticeable symptoms but exacerbates other conditions.
As these blood cells can outcompete others, this genetically unique clone strain can replace nearly 100 percent of a person's blood over time. Analyzing the DNA of blood cells from 1,362 people with Alzheimer's and 4,368 individuals without, Bouzid and the team found a 30–50 percent lower risk of Alzheimer's in people with the blood mutation. This is a similar degree of protection as a genetic variant known to reduce Alzheimer's, JaiswalIt also suggests the mutation impacts tissues other than red blood cells.
Thanks to 12 donors, eight who had lived with CHIP and four without, the team identified such CHIP-carrying myeloid cells in brain tissue. Seven of eight CHIP carriers had an increase in immune cells.'s connective tissue. But these cells that originated from bone marrow had somehow snuck into the brain and taken on the immune system role of microglia.
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