Lower temperatures might not warm your heart, but they could make for a longer life.
– are linked to the build-up of bad proteins, so discovering how temperature affects this process is a significant step forward in terms of finding ways to potentially slow or even stop this deterioration from happening.is unlikely to be a therapy option any time soon, understanding the workings of processes that cold temperatures kick start could help us to replicate them through the use of targeted treatments.
This was done through structures called proteasomes that break down protein waste, and in particular the worm version of the PA28γ/PSME3 proteasome activator found in humans. It only took a moderate drop in temperature in order to get the activator working and cleaning up potentially dangerous protein accumulation.The team also found a bit of clever genetic engineering could dial-up proteasome activity, achieving the same result without cooling.
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