Our brains experience a litany of changes as we age, right down to the way its DNA is translated.
Now a new study has found that in people with cocaine use disorder those changes can accumulate at an accelerated rate.known to humans. It interferes with the brain's reward pathways, forcing its cells to continue to pump out pleasurable signals until the drug wears off.But precisely how a drug thatbetween brain cells evokes addictive behaviors that in turn manifest in substance abuse is a chain of events researchers are still trying to understand.
In this study, the researchers used two different epigenetic clocks to try to account for any variation. "This could be caused by cocaine-related disease processes in the brain, such as inflammation or cell death." However, the researchers acknowledge that their study was small and more research is required, perhaps to see what molecular changes the brain accrues over time with ongoing drug use.
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