A drug called bempedoic acid is an option for patients who cannot tolerate statin drugs because of muscle pain or other side effects
Fewer heart attacks and surgical procedures
“The benefits of bempedoic acid are now clearer,” wrote John H. Alexander, the director of cardiovascular research at the Duke Clinical Research Institute, in an accompanying editorial. “It is now our responsibility to translate this information into better primary and secondary prevention for more at-risk patients, who will, as a result, benefit from fewer cardiovascular events.
“In the current era where we have other cholesterol-lowering drugs, people are not going to use a drug that does not have demonstrated outcome benefits,” Nissen said. “People want evidence. Everybody has been waiting for this trial.” have a proven record of reducing heart attacks in at-risk patients and preventing additional heart attacks in those who have already had one. Denying at-risk patients a proven treatment to study a new drug would be unethical.But there are many patients who have tried statins but stopped taking them because of undesirable side effects — most often because of muscle pain, but some also complained of cognitive effects including fuzzy thinking or memory lapses.
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