Chemists find the surprisingly simple way mammals keep their bloodstream in balance princeton
, Joshua Rabinowitz, professor of chemistry and the Lewis-Sigler Institute for Integrative Genomics, reports with his research group that much of metabolic balance in animals doesn't require any sensing at all. A chemical principal known as mass action oversees, automatically clearing many of these circulating metabolites when they show up in the bloodstream without the production of a signal hormone.
More broadly, it illustrates how chemistry can illuminate and even solve longstanding biological questions. When a metabolite concentration increases significantly, the body can counteract it through two means: by reducing the endogenous production, or by trying to burn more quickly.
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