New health research suggests novel combination therapy for triple-negativebreastcancer lsu
]. RTK-activated androgen-independent AR signaling may partially complement or compete with canonical AR signaling activity, which results in only modest efficacy of AR antagonism in AR positive TNBC treatments. Current AR-targeting studies focus on the blockade of the canonical AR signaling pathway, while the role of androgen independent AR signaling pathway in TNBCs is neglected.
Due to the observed inhibitory effects of ceritinib in the AR signaling cascade, we proposed that an AR inhibitor and ceritinib would be synergistic and more effective in a combination strategy. In this study, we discovered that the combination of enzalutmide and ceritinib is an effective regimen in AR−TNBC. The efficacy of these combination strategies were evaluated in multiple model systems.
This study has crucial implications in the field of drug and target discovery in the context of breast cancer. The results from our study have immediate implications for clinical translation for this difficult-to-treat breast cancer subtype, which would benefit significantly from effective targeted therapeutic regimens. Our innovative approach to test repurposed FDA-approved drugs in new clinical contexts can be applied to all cancer tumor types and is not limited to breast cancer.
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