N&V: Armored CAR T cells show early signs of clinical activity in patients with castration-resistant prostate cancer, paving the way for further development and optimization. ProstateCancerAwarenessMonth
Cancer progression is often fueled by a preponderance of genetic aberrations such as mutations, amplifications and divergently expressed genes.
These can lead to newly expressed peptides that are entirely absent from normal human tissues, or to peptides that are expressed at higher levels in tumors, but are also expressed at lower levels in other tissues — the latter are known as ‘tumor-associated antigens’.
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