Cancer Treatment with DNA “Nanotransporters” uMontreal_news DNA Nanotransporters CancerTreatment Treatment
Nov 3 2022Reviewed by Emily Henderson, B.Sc. Researchers from the Université de Montréal in Canada have created and verified a new class of DNA-based drug transporters that are 20,000 times smaller than a human hair and could enhance cancer treatment and other diseases.
Modern medicine continues to struggle with maintaining the ideal drug concentration level in the blood. Patients must take numerous doses at regular intervals since most drugs degrade quickly, and they frequently forget to do so. The drug concentration in each patient’s blood also varies considerably because each has a unique pharmacokinetic profile.
Arnaud Desrosiers, a Ph.D. student at UdeM, is the study’s first author. He discovered and created two DNA transporters: one for the antimalarial quinine and the other for the chemical doxorubicin, frequently used to treat leukemia and breast cancer. The team found that a particular drug-transporter formulation enables doxorubicin to be kept in circulation and significantly inhibits its diffusion toward important organs like the heart, lungs, and pancreas.
He further added, “Additionally, these transporters could also be combined with human-designed liposomic transporters that are now being employed to deliver drugs at various rates.”
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