Endocrinologists are throwing cold water on TikTok's claims that the supplement berberine produces the same amount of weight loss seen with new medications like semaglutide or tirzepatide. EndoTwitter
The trials also document the many side effects of taking the drugs, primarily gastrointestinal in nature. The short- and long-term effects of berberine, on the other hand, are less clear. Some of the clinical trials reportedIts perception as a naturally derived option for weight loss, though, might encourage people to overlook the potential interactions that berberine could have with other drugs, according to Almandoz.
He says clinicians considering natural products or nutraceuticals for patients should check for potential side effects and find reliable database sources to determine any potential medication interactions for patients. But the unregulated nature of berberine makes this challenging, Almandoz adds. The dosage, formulations, and quality of berberine vary in each study and each product because supplements don't need to pass through the checks and balances of the FDA to land on shelves.
The lack of regulation could incentivize some companies to add stimulants to enhance any weight loss effect that the supplement may have. Those additives might interact with other health conditions or cause side effects like anxiety, says Almandoz. Berberine should also not be taken during pregnancy or while breastfeeding, and it is unsafe for young children; in newborns and children, the supplement can cause higher levels of
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