Building resilient brains: strategies for promoting brain health in older adults LancetLongevity brainhealth brain health publichealth prevention
By Neha MathurJun 21 2023Reviewed by Lily Ramsey, LLM In a personal view published in The Lancet Healthy Longevity, researchers reviewed the overarching theme of brain health from the perspective of aging and preventive care.
At a molecular level, telomeres have emerged as markers of aging, though their length does not always correlate with other brain aging markers, e.g., alterations in hippocampal volume. Similarly, neuroinflammation is an important contributor to accelerated brain aging. Though high amounts of interleukin-6 have helped predict cognitive decline in longitudinal studies, there is a lack of appropriate radiographic or biological predictors of brain aging.
It is not just the absence of structural and molecular pathologies but the preservation of thought processing, executive planning, sensory and motor function, and memory and emotional connection. Advancements in treatment techniques for mild cognitive impairment and dementia emphasize the significance of high-risk approaches, e.g., lecanemab. Though the interventions in high-risk groups are effective, their effects could be small.
The American Heart Association updated the concept of Life's Simple seven and added sleep as the eighth modifiable health behavior that, when optimal, lowered the risk of vascular, metabolic, and cognitive health decline. The other seven factors are a healthy diet, physical activity, abandoning smoking, maintaining a healthy weight, normal lipid concentrations, blood pressure, and normoglycaemia.
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