Bruce Willis' Dementia Is Not Your Grandpa's Dementia

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Bruce Willis' Dementia Is Not Your Grandpa's Dementia
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A neuroscientist reviews how FTD differs from more common forms of dementia with little initial impact on a patient's broader memory and associated cognitive abilities.

When we see or hear or otherwise sense something that induces fear, alarm, or a potential reward, the salience network in our brain acts as a kind of gatekeeper. First, it assesses the emergent or changing situation, then it rapidly initiates an emotional and physical response. As I sit with a patient in obvious distress in my office, my salience network turns on an empathetic alarm. My brain and body immediately adjust to initiate appropriately sympathetic reactions.

which is linked to improvements in the regulatory control of the autonomic nervous system — one of the key response-mediating targets of the network's von Economo neurons.with a full complement of von Economo neuronsThis neuroscientist can foresee a day when we routinely assess the integrity of this important brain system and more reliably maintain its good health.

Michael Merzenich, PhD, is often credited with discovering lifelong plasticity, being the first to harness plasticity for human benefit , and for pioneering the field of plasticity-based computerized brain exercise. He is professor emeritus at UCSF and a Kavli Laureate in Neuroscience, and he has been honored by each of the US National Academies of Sciences, Engineering, and Medicine. He may be most widely known for a series of specials on the brain on public television.

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