A breakthrough project mapping brain changes in nearly 1,300 people diagnosed with six different types of mental illness has revealed the extraordinary diversity of brain changes found in people with conditions like major depression and schizophrenia.
The study, published in Nature Neuroscience and led by researchers at Monash University’s Turner Institute for Brain and Mental Health and School of Psychological Sciences, used brain imaging to measure the size, or volume, of over 1000 different brain regions.
“We used a statistical model to establish expectations about brain size given someone’s age and sex. We can then quantify how much an individual person’s brain volume deviates from these expectations, much like the growth charts commonly used for height and weight in pediatrics,” said Professor Fornito.
“It’s possible that this circuit-level overlap explains commonalities between people with the same diagnosis, such as, for example, why two people with schizophrenia generally have more symptoms in common than a person with schizophrenia and one with depression.”
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