Black sea urchin extract shows promise in combating atherosclerosis Atherosclerosis AntiInflammatory Antioxidant Cardiovascular Inflammation Medicine BlackSeaUrchin Arbacialixula Nutrients_MDPI UniSalento
Study: In Vitro Anti-Inflammatory and Vasculoprotective Effects of Red Cell Extract from the Black Sea Urchin Arbacia lixula. Image Credit: Alexey Masliy / Shutterstock
In the current study, scientists have evaluated the potency of coelomic red-cell extracts of the black sea urchin Arbacia lixula to prevent endothelial cell activation and monocyte recruitment major hallmarks of atherosclerosis. Study experiments were conducted by culturing human endothelial cells in the presence or absence of black sea urchin extracts for four hours, followed by exposure to TNF-α for 0 – 18 hours.
However, the pretreatment of endothelial cells with black sea urchin extract led to a significant reduction in the number of adhered monocytes in response to TNF-α exposure. Furthermore, the pretreatment was found to reduce the expressions of two adhesion molecules, vascular cell adhesion protein 1 and intercellular adhesion molecule-1 , on the endothelial cells. This might be the reason for reduced monocyte adhesion on TNF-α-activated endothelial cells.
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