Mutations that saved lives from the plague are causing auto-immune diseases today.
, surrounded mutations in a gene called ERAP2."That's huge, it's a huge effect, it's a surprise to find something like that in the human genome," Professor Luis Barreiro, from the University of Chicago, told me.
The gene comes in different versions - those that work well and those that do nothing - and you get a copy from each parent. And the survivors had children and so passed those helpful mutations on so they suddenly became much more common. "So those scars from the past still impact our susceptibility to disease today, in a quite remarkable way," said Prof Barreiro.
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