Bioengineered soluble ACE2 for brain protection against SARS-CoV-2 infection biorxivpreprint NorthwesternU ChariteBerlin UChicago brain SARSCoV2 ACE2 COVID19 coronavirus covid
By Bhavana KunkalikarDec 12 2022Reviewed by Danielle Ellis, B.Sc. In a recent study posted to the bioRxiv* preprint server, researchers compared the efficiency of bioengineered soluble angiotensin converting enzyme-2 concerning brain protection during coronavirus disease 2019 .
About the study In the present study, researchers examined the impact of an ACE2 618-DDC-ABD, a bioengineered soluble ACE2 protein with a sufficient duration of action and strong SARS-CoV-2 binding affinity. The team utilized k18-hACE2 mice, which expressed human ACE2 in its entirety and are sensitive to SARS-CoV-2 infection. Five to nine days after infection, animals with this viral load always succumb to the disease. The researchers examined the effects of pre-and post-treatment with the ACE2 618-DDC-ABD protein and compared intranasal and intraperitoneal delivery effects using distinct methodologies.
On day five, 0% of untreated and infected mice survived. Most mice that were administered ACE2 618-DDC-ABD post-viral inoculation experienced significant weight loss and deteriorating clinical score, while a few recovered and survived up to day 14.
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