Beyond COVID-19: the potential future applications of mRNA vaccines MCRI_for_kids UniMelb TheDohertyInst mRNA RNA vaccine vaccination mRNAvaccine
By Tarun Sai LomteJul 6 2022Reviewed by Danielle Ellis, B.Sc. In a recent study published in the Medical Journal of Australia , researchers described the production, mechanisms, and potential applications of messenger ribonucleic acid vaccines.
Large-scale production of mRNA vaccines could occur in a short time with appropriate facilities. Once delivered into the host cell, ribosomes translate mRNA into the protein of interest. Typically, the protein is expressed on the cell surface to stimulate the cellular immune system. Host cells secrete proteins that other antigen-presenting cells capture and present/display for antibody-mediated immune responses.
Related StoriesSome safety issues have emerged following the administration of SARS-CoV-2 mRNA vaccines, such as myocarditis and pericarditis, albeit the consequences were mild to moderate and not fatal. Although the mechanism of these events is unknown, it could be antigen-specific or perhaps general to the vaccine itself. Nonetheless, continued surveillance would be critical to the development of newer mRNA vaccines in the future.
mRNA vaccines and cancers For over two decades, mRNA vaccines have been explored extensively as cancer therapeutics with little success. Lately, the research interest in cancer vaccines has increased significantly, triggered by the durable and dramatic responses observed with immune checkpoint inhibitors in some malignancies and technological advances.
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