Best antioxidants to prevent dementia
The researchers tested associations and interactions of serum vitamins A, C and E, and total and individual serum carotenoids and interactions with incident Alzheimer's disease and all-cause dementia.
For lutein+zeaxanthin, every standard deviation increase was associated with a 7% decrease in risk for dementia . This association was attenuated somewhat after adjusting for socioeconomic status. This relationship remained strong in models adjusted for sociodemographic and socioeconomic factors but attenuated in subsequent models.
"This analysis of an observational study found that the most important carotenoids in potentially protecting the brain may be lutein+zeaxanthin and beta-cryptoxanthin. However, randomized controlled trials are needed to prove causality," said Ferrucci. The findings are"challenging," they add, because they may lead to the hypothesis that inhibition of oxidative damage by antioxidants might have beneficial effects on preventing dementia.
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