Benefits of Nanocarbon-Based Field-Effect Transistors in Biosensors ChemBioChem biosensors nanomaterials carbon nanotechnology nanoscience nanobiotechnology
By Bhavna KavetiOct 10 2022Reviewed by Susha Cheriyedath, M.Sc. Field-effect transistor devices based on functionalized nanocarbon materials are a promising technology for biomolecular sensing applications. Nanocarbon-based field-effect transistor devices allow for label-free detection of biomolecules with the advantage of easy and direct electrical readout compared to most routine techniques.
NC-FET Biosensors and Their Advantages A biosensor is an analytical device incorporating a biological recognition element in direct spatial contact with a transduction element. This integration ensures the rapid and convenient conversion of biological events to detectable signals. Although metal-oxide-semiconductors or organic semiconductors were proposed as cost-effective and scalable channel materials, their low on/off ratio, slow mobility, poor signal-to-noise ratio, and short lifetime restrict their application. Carbon nanomaterials can overcome these shortcomings due to their unique physical and chemical properties, increasing the sensitivity in detecting target biomarkers.
Furthermore, device uniformity has been previously achieved using semiconducting CNT dispersion methods, and functionalization uniformity are yet to be addressed to regulate the number of biomolecules that may connect to an NC-FET device.
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