Nature - BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection
. The new variants’ receptor binding and immune evasion capability require immediate investigation. Here, coupled with Spike structural comparisons, we show that BA.2.12.1 and BA.4/BA.5 exhibit comparable ACE2-binding affinities to BA.2. Importantly, BA.2.12.1 and BA.4/BA.5 display stronger neutralization evasion than BA.2 against the plasma from 3-dose vaccination and, most strikingly, from post-vaccination BA.1 infections.
Yunlong Cao, Ayijiang Yisimayi, Fanchong Jian, Weiliang Song, Tianhe Xiao, Jing Wang, Ran An, Xiao Niu, Sijie Yang & Xiaoliang Sunney XieYunlong Cao, Yuanling Yu, Peng Wang, Yao Wang, Jing Wang, Haiyan Sun, Lijuan Zhao, Jiang Zheng, Lingling Yu, Can Li, Na Zhang, Rui Wang, Xuetao Song, Linlin Zheng, Qingqing Gu, Fei Shao, Youchun Wang, Xiangxi Wang, Junyu Xiao & Xiaoliang Sunney XieAyijiang Yisimayi, Weiliang Song, Shuo Du, Jing Wang, Zhiying Zhang, Pulan Liu & Junyu XiaoFanchong...
Joint Graduate Program of Peking-Tsinghua-NIBS, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, ChinaCAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, P.R. ChinaDivision of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control , Beijing, P.R.
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