Researchers discuss SARS-CoV-2 vaccine effectiveness in preventing long COVID in fully vaccinated individuals.
By Pooja Toshniwal PahariaOct 19 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study published in Antimicrobial Stewardship & Healthcare Epidemiology, researchers discuss severe acute respiratory syndrome coronavirus 2 vaccine effectiveness in preventing post-coronavirus disease 2019 conditions such as long COVID in fully vaccinated individuals.
Long COVID can present with persistent neuropsychiatric, respiratory, and cardiovascular symptoms four or more weeks an acute SARS-CoV-2 infection. Long COVID has raised significant public health concerns, as a sizeable proportion of individuals develop long COVID symptoms and associated complications that significantly impact the quality of life and pose a considerable healthcare burden.
Databases such as the Cumulative Index to Nursing and Allied Health, PubMed, Cochrane Central Register of Controlled Trials, EMBASE, Web of Science, and Scopus were searched between December 1, 2019, and June 2, 2023, for records evaluating VE against long COVID among individuals who had received two COVID-19 vaccinations.
Two researchers independently performed component quality assessments and resolved disagreements by consensus. The diagnostic odds ratio was calculated for long COVID between double-dose COVID-19 vaccinees and their unvaccinated counterparts after pooling values from all included studies. The team estimated VE as 100% multiplied by the value.
COVID-19 vaccines did not protect individuals against long COVID who were vaccinated after the SARS-CoV-2 infection. Complete vaccination before contracting SARS-CoV-2 significantly reduced long COVID incidence across different COVID-19 waves, including the SARS-CoV-2 Omicron VOC wave. These findings were homogeneous among the included studies and there was no publication bias among the studies included in the meta-analysis. Concerning evidence quality among 32 studies, 28, three, and one were of good, fair, and poor quality, respectively.
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