The test could help ensure a successful pregnancy but still leaves hopeful parents with some difficult decisions
In clinics today, fertility patients using in vitro fertilization are routinely advised to pay for an expensive supplemental test called preimplantation genetic testing for aneuploidy , in which a handful of cells are removed from the embryo to examine their DNA. For those who can afford it, PGT-A is popular because it can flag genetic abnormalities that increase the odds that a pregnancy, should it occur, will end in miscarriage.
Proponents of the test have pushed back strongly on this criticism. They say that PGT-A benefits decision-making for anyone who can afford it and provides patients with realistic information on each embryo’s odds of viability. PGT-A is also credited with reducing the risks and costs associated with earlier iterations of IVF.
But while the rationale for use of PGT-A appears sound, research has exposed the limitations of embryo biopsy. As lead author David Barad of the Center for Human Reproduction points out, the cells biopsied are a small sample of the whole. They are pulled from the tissue that will eventually form the placenta and not the fetus itself.
In their study, Barad and his co-authors transferred both mosaic and fully aneuploid embryos after patients were denied the opportunity to use them at other clinics. Their findings, in line with previous work, demonstrate that mosaic embryos are frequently capable of generating a successful pregnancy. Interestingly, in follow-up testing of a fetus or subsequent child, the rogue cell lines with added or missing DNA have often disappeared altogether.
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