Airpollution is linked to lower COVID-19 vaccine responses ISGLOBALorg
"The collaboration of all volunteers in the GCAT cohort, with more than ten years of data, has allowed us to reliably estimate the level of environmental exposure of all participants," says Rafael de Cid, co-author of the study and GCAT|Genomes for Life project director.and BC was associated with a 5% to 10% reduction in vaccine-induced spike antibodies. The decrease in antibodies was shown both for early IgM responses and late responses measured by IgG.
"Air pollution can induce chronic inflammation, which has been associated with a negative effect on vaccine efficacy," explains Carlota Dobaño, co-senior author of the study, together with Cathryn Tonne."Our findings are consistent with evidence thatThe fact that previous infections lead to higher vaccine responses could explain why the effect of pollutants was only observed in people without a prior infection.
The study did not look at whether the reduction in antibody responses led to an increased risk of breakthrough infections and their severity."However, our findings add to growing body of evidence on the adverse effects of air pollution even at the relatively low levels observed in Western Europe.
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