Advances in computational science are delivering insights into how to improve maternal mortality, deliver better therapies for breast cancer patients, and more
Women may comprise half the world’s population, but research on the major conditions affecting their health have longthat of men. One way some scientists are trying to change this is by harnessing the power of artificial intelligence and computational medicine to extract findings that would otherwise be missed.
Greater interest from the growing number of young, female engineers has also been crucial in advancing the field, says Michelle Oyen, the director of the Center for Women’s Health Engineering at Washington University in St. Louis, which draws from both the engineering and medical schools. The idea of using computer simulations to study pregnancy problems, as her lab does, “seems to capture young students’ imaginations,” she says. “In many cases, they say, My mom had this or my friend had this.
Yankeelov and his team sought to develop mathematical equations that could be applied to a single LABC patient. They have derived four differential equations that calculate how each tumor grows and responds to treatment. The equations utilize factorsto influence the progression of the disease, like how the tumor cells migrate, proliferate, and interact with the tissue surrounding them, and how they respond to an early course of therapy.
Wang and his colleagues have created a unique detection device—called an electromyometrial imaging system—which is placed on the abdomen and contains 250 electrodes that record a half-million bits of data per second. Computers transform the data into real-time, dynamic visual images of the uterus as it experiences each contraction .
Oyen relies on machine learning to create a dynamic computational model of the placenta. “We take the geometry of the structure and properties of the tissues and put them into the computer, then explore what happens if you vary the properties of the tissues over hundreds of simulations,” she says. This research cannot be done in people for obvious ethical reasons, nor in animals because their placentas are markedly different, she says.
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