On NationalProteinDay, learn more about the AI revolution in protein structure prediction.
, mostly in bacteria. But in eukaryotes—organisms from yeast to people—the interacting partners are often unknown. Identifying them and predicting how they come together in a complex was too high a bar for the original programs.
To find proteins that may form complexes together, the team began by comparing the amino acid sequence of all 6000 yeast proteins to those from 2026 other fungi and 4325 other eukaryotes. The comparisons allowed the researchers to track how those proteins changed over the course of evolution and identify sequences that appeared to change in tandem in different proteins.
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