Genomic profiling of colorectalcancer patients revealed that fewer targetable alterations were found in African heritage patients' tumors compared to those of European backgrounds CRC precisionmedicine genomics healthdisparities
than individuals of other heritages, a disparity attributed to many factors, including socioeconomic, environmental, and genetic influences, as well as less access to care.
Overall, the numbers to date show a clear trend: the incidence of and mortality from CRC are higher among Black patients of other populations. However, the extent to which genetic difference plays a role in these disparities remains unclear. Tumor and normal tissues from the patients underwent next-generation DNA sequencing with a panel that covers 505 cancer-associated genes.
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