The compound inside the mushroom could be used to treat Alzheimer's.
“Laboratory tests measured the neurotrophic effects of compounds isolated from Hericium erinaceus on cultured brain cells, and surprisingly we found that the active compounds promote neuron projections, extending and connecting to other neurons,” added Meunier.
“Using super-resolution microscopy, we found the mushroom extract and its active components largely increase the size of growth cones, which are particularly important for brain cells to sense their environment and establish new connections with other neurons in the brain.” Co-author UQ’s Dr. Ramon Martinez-Marmol added that the newly-discovered compound may have applications in the treatment and protection against neurodegenerative cognitive disorders such as Alzheimer’s disease.
“Our idea was to identify bioactive compounds from natural sources that could reach the brain and regulate the growth of neurons, resulting in improved memory formation,” Dr. Martinez-Marmol said.Dr. Dae Hee Lee from CNGBio Co, which was part of the research project, said lion’s mane mushrooms had been used in traditional Chinese medicine since antiquity to treat various conditions and maintain overall well-being.
“This important research is unraveling the molecular mechanism of lion’s mane mushroom compounds and their effects on brain function, particularly memory,” Lee said.
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