Researchers announced that when they injected 52 male mice with an experimental compound called TDI-11861, it temporarily inhibited an enzyme that helps sperm move. The results point to a short-term birth control option for men.
Over time, they refined TDI-11861. In mice, the drug didn’t appear to interfere with sexual functioning or cause any side effects. And most importantly, the sperm were normal again a day later.
To test the safety of their compound, the Cornell team continuously infused it into male and female mice via a pump for six weeks. They noted no side effects, including no kidney issues. They’re now testing the compound in rabbits, which have reproductive organs that are more similar to those of humans.
Some men might prefer a non-hormonal, temporary option. “I think it’s a really wonderful idea and would be very much appreciated by a lot of people who would not maybe want to take a pill every day,” says Gunda Georg, a professor of medicinal chemistry at the University of Minnesota, who researches male and female contraceptives and wasn’t involved in the new work. “I think we need to have many different options for contraception for men and also for women.
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