A Novel Cannabinoid May Help Protect the Brain From Aging

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A Novel Cannabinoid May Help Protect the Brain From Aging
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A new study finds that a previously overlooked compound found in food may be a key to slowing down memory loss

. Currently, there are no therapeutic agents that can effectively counteract the damaging actions of the activated microglia or even slow down the progression of these disorders.My research has shown that targeting the mechanisms underlying chronic neuroinflammation by stimulating cannabinoid receptors may be a promising strategy.

PEA’s actions are beneficial because it activates two important receptors that control inflammation and the sensation of pain, PPAR-α and TRPV1. This dual action underlies PEA’s anti-inflammatory, antioxidant, analgesic, and neuroprotective effects. PEA is safe to consume; some countries have allowed products containing PEA to be sold as a food supplement for humans. The recommended dose is typically 600 to 1,200 milligrams per day.

Human and animal studies have provided solid neurobiological evidence for the therapeutic benefits of PEA, particularly related to changes seen in the brains of patients with Alzheimer’s disease. PEA supplementation reduced brain inflammation, reduced the expression of amyloid protein, reduced the negative effects of tau protein in the hippocampus, and reduced glial activation. Taken together, these effects were associated with improved neuronal survival and widespread neuroprotection.

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