The human genome's inner workings could be revealed through new Cornell-developed technology. Researchers from Oxford Nanopore Technologies, Weill Cornell Medicine, and the New York Genome Center have created a new technique to evaluate the three-dimensional structure of the human DNA, or how the g
Scientists were able to examine tens of millions of three-dimensional locus groupings with the help of the new technology which they named Pore-C.Researchers from Oxford Nanopore Technologies,
For example, previous technology to examine the genome’s three-dimensional structure enabled researchers to investigate how often two loci, or physical sites on the genome, interact with one another. Traditionally, pairs of loci known as enhancers and promoters—components in the genome that interact with one another to control gene expression—have been discovered.
They adapted Hi-C , a standard approach that evaluates a combination of DNA and protein to assess three-dimensional genome structure, to nanopore sequencing, or the high-throughput sequencing of long, continuous strands of DNA molecules. The new test, named Pore-C, allowed the researchers to examine tens of millions of three-dimensional locus clusters.
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