The more researchers looked into the compound BnOCPA, the more properties they discovered that could open up new areas of pain management with fewer side effects than opioids.
The new discovery of a non-opioid analgesic with potentially fewer side effects compared with other potent painkillers is offering the opportunity of new pain-relieving treatments., said that in the UK between one third and one half of the population report
For their research, the team at School of Life Sciences, University of Warwick, together with colleagues at the University of Cambridge, University of Bern, Monash University, Coventry University and industrial collaborators, investigated a compound called BnOCPA . In test model systems they found it to be non-addictive, in addition to it having potent analgesic effects.
Many drugs act via proteins on the surface of cell surfaces that activate adapter molecules called G proteins. The activation of G proteins can lead to many cellular effects. BnOCPA is unique, they said, in that it "only activates one type of G protein", leading to "very selective effects" and thus "reducing potential side effects". In their laboratory study they found that in addition to being a potent and powerful analgesic, it does not cause sedation, bradycardia, hypotension, or respiratory depression.
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