Tirzepatide, a new diabetes drug administered weekly through injection, helped those with type 2 diabetes meet blood glucose goals 4 to 12 weeks earlier than those receiving conventional diabetic drugs. The phase 3 SURPASS trials, which were published in 2021, proved that tirzepatide reduces bloo
Type 2 diabetes is a condition that affects the way the body regulates and uses glucose as fuel.
“Tirzepatide is unique because it mimics two natural insulin-releasing and appetite-suppressing hormones in one injection”, says lead author Dr. Adie Viljoen, a Consultant Metabolic Physician and Chemical Pathologist from the East and North Hertfordshire NHS Trust, UK.“The speed we are seeing in glucose-lowering and weight loss is beyond anything else we have available right now and it may put adults with type 2 diabetes in a better position for preventing long-term complications.
The SURPASS-2 and SURPASS-3 trials compared different doses of tirzepatide with a once-weekly injectable semaglutide 1 mg as an add-on therapy to metformin, or long-acting insulin , as an add-on therapy to metformin with or without a sodium-glucose cotransporter-2 inhibitor, respectively [3]. The average time to achieve an HbA1c level of less than 7% was around 8 weeks for all tirzepatide doses compared to 12 weeks for both semaglutide and iDeg; to reach 6.5% or less was 12 weeks versus about 16 weeks and 24 weeks, respectively.
Mild to moderate gastrointestinal adverse events such as nausea, vomiting, and diarrhea were noted in participants taking tirzepatide and were most frequently reported during the dose escalation period and decreased over time.
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