A new Alzheimer’s disease monoclonal antibody treatment that takes aim at a new target for the progressive disease has shown promising results, according to Boston researchers.
The Mass General Brigham treatment strategy mimics a genetic mutation that’s resistant to the neurodegenerative disease. In the study, the treatment was reportedly effective at reducing abnormal tau proteins associated with Alzheimer’s.
To turn those gene findings into a potential treatment, the researchers have now developed antibodies that could target interactions between APOE and proteins. “Our 7C11 antibody was able to target interactions responsible for a major genetic risk factor for sporadic Alzheimer’s,” said co-corresponding author Joseph Arboleda-Velasquez, an associate scientist in the Department of Ophthalmology at Mass Eye and Ear.
Meanwhile, the National Institutes of Health recently awarded a $13.7 million grant to Boston University researchers investigating the genetics of Alzheimer’s disease. The researchers hope to identify new targets for developing drugs to treat or slow processes leading to the disease.
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