They called the model 'MultiVelo.'
The latest study by the University of Michigan revealed that a mathematical model that can be used in stem cell therapy will be more effective in treatments. This model will allow scientists to finally figure out the order of genetic operations inside developing cells., it was said that regenerative medicine is still in its early stages, with only a few stem cell therapies proving to be beneficial and scientists have been working on new stem cell treatments for decades.
Researchers were unable to observe gene expression in a single cell until recently. They can today because of single-cell sequencing technology. The cell is destroyed when it is measured, thus it is still difficult to visualize the timing of changes. “To address this, we developed an approach based on models in basic physics,” explained Welch, “treating the cells like they are masses moving through space and we are trying to estimate their velocity.”
The model, named "MultiVelo", predicts the direction and speed of the molecular changes the cells are undergoing.“Our model can tell us which things are changing first–epigenome or gene expression--and how long it takes for the first to ramp up the second,” said Welch.
“One of the big problems in the field is the artificially differentiated cells created in the lab never quite make it to full replicas of their real-life counterparts,” said Welch. “I think the biggest potential for this model is better understanding what are the epigenetic barriers to fully converting the cells into whatever target you want them to be.
Österreich Neuesten Nachrichten, Österreich Schlagzeilen
Similar News:Sie können auch ähnliche Nachrichten wie diese lesen, die wir aus anderen Nachrichtenquellen gesammelt haben.
Neuronal defects in a human cellular model of 22q11.2 deletion syndrome - Nature MedicineTo raise awareness of StemCellAwarenessDay, here is a study using a human cellular model to investigating the mechanisms of neuronal defects in 22q11.2 deletion syndrome (digeorgesyndrome)
Weiterlesen »
Multi-omic single-cell velocity models epigenome–transcriptome interactions and improves cell fate prediction - Nature BiotechnologyMathematical model could bring us closer to effective stem cell therapies umich NatureBiotech
Weiterlesen »
Human neurons merge with rat brain to control sensesTransplanted brain cells could pave the way for new neuropsychiatric studies
Weiterlesen »
Maturation and circuit integration of transplanted human cortical organoids - NatureHuman cortical organoids transplanted into the brain of newborn rats develop functional connectivity with host sensory circuits and shed light on neuronal dysfunction in Timothy syndrome. NBThighlight
Weiterlesen »
Hematopoietic stem cell transplantation chemotherapy causes microglia senescence and peripheral macrophage engraftment in the brain - Nature MedicineHematopoietic stem cell transplantation chemotherapy with busulfan causes senescence of brain microglia, rapid loss of adult neurogenesis and engraftment of peripheral donor macrophages into the brain of mice post transplantation.
Weiterlesen »