The difficult work of trying to understand Parkinson's disease continues, with a new study showing that the condition might be triggered earlier than had previously been thought.
Two genes, Parkin and PINK1, are responsible for mitophagy, and it'sthat mutations in these genes that prevent them from doing their jobs properly mean a much higher risk of developing Parkinson's.
The new research adds to this knowledge by highlighting mutations in Parkin as being responsible for dysfunction in the synapses specifically. It's a mechanism we didn't know about before, and it seems to be the earliest sign yet ofIt also teaches researchers more about how Parkin and PINK1 operate independently from each other.
Included in the samples were neurons from two sisters with Parkinson's. While both were born without the PINK1 gene, only one of them was completely missing the"There must be a complete loss of Parkin to cause Parkinson's disease," Krainc."So, why did the sister with only a partial loss of Parkin get the disease more than 30 years earlier?
That mystery is explained by Parkin's previously unknown function in controlling dopamine release through synapses, aside from the work it also does in neuron recycling. Further down the line, we may be able to control it., with 90,000 diagnoses in the US alone every year. Those numbers are expected to increase as populations across the globe keep aging.
Both the discovery of the mechanism and its appearance in the brain before any other potential triggers are going to be crucial in the ongoing pursuit of
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